August 13, 2020


Classics in Total Synthesis. By K.C. Nicolaou and E. J. Sorensen. Article (PDF Available) in Molecules 3(2) · February with 2, Reads. This book is essential for any synthetic organic chemist.[ ]. K. C. NICOLAOU, E. J. SORENSEN. CLASSICS IN. TOTAL. Page 2. Classics in Total Synthesis K. C. Nicolaou and. – E. J. Sorensen. VCH.

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Using his didactically skillful approach, K. Nicolaou compiles and contrasts the important synthetic methods that lead to a complex molecule with valuable properties. All the key steps of the synthetic pathway are explained, with major developments highlighted in blue boxes.

Classics in Total Synthesis

Retaining his excellent, proven approach, world-famous chemist and passionate teacher K. Nicolaou compiles here the important strategies and tools employed to construct complex molecules. For a total of 42 syntheses of 25 challenging natural products he explains all the key steps of the synthetic pathway, highlighting the major developments in blue-boxed sections for easier understanding, and contrasting these to other synthetic methods.

Similar to its predecessors and completing the trilogy, this textbook analyzes the syntheses in a didactic manner, with several chapters including mini-reviews of key methodologies, and an emphasis on the history, mechanism, scope, and generality of the reactions.

In contrast to the first two volumes, this new one features full-color frontispieces. A wonderful tool for learning and teaching and a must-have for all current and future organic and biochemists. KGaA – Provider – www.

Nicolaou compiles and contrasts the important synthet. Short Description Using his didactically skillful approach, K. Shipping Add to Cart. Description Content Reviews Author information Retaining his excellent, proven approach, world-famous chemist and passionate teacher K. Nowadays, books that syntnesis on the area of organic synthesis are numerous enough to fill whole inventories of libraries.

But of that multitude, only a few books have been as outstanding in recent years as the series Classics in Total Synthesis, written by K.

Classics in Total Synthesis: Targets, Strategies, Methods

Nicolaou with various co-authors. This series can therefore already be justifiably called a classic in itself. Likewise, the third volume of this series, published by Wiley-VCH in Februarywill surely continue the success of the previous volumes, and will certainly be a must-have in the libraries of totql orientated groups. The concept incolaou the preceding volumes has been closely retained. In 26 chapters, including an introductory chapter, syntheses of more than 40 natural products or natural product core structures are discussed in detail.


The syntheses, together with historical excursions, have been taken from literature of the years to Each chapter begins with background information about the discovery, structure elucidation, and biological significance of the target molecule s.

After describing retrosyntheses that have been achieved, and any preliminary synthetic work, the chapter gives a very detailed nicolaku of the synthesis of the target structure, including almost all the individual steps. All literature references are clearly identified by chapter endnotes, thus allowing rapid access to the primary sources. The chapter ends with a short summary and a well-chosen, detailed, and extensive list nicokaou references. This alone is one of the great strengths of the book, and provides every synthetic chemist with an excellent nicolzou for the solution of his or her own synthetic problems.

Also particularly valuable for the reader are the short reviews on specific topics, which have the scope and style of review articles. Thus, one finds surveys on current topics of interest such as organocatalysis Chapter 7: The review of asymmetric halogenation reactions Chapter Novelties of this third volume compared to the previous ones are mainly concerned with the detailed contents.

The depth of mechanistic discussions has been greatly increased. The introductions to the chapters often feature insights into the biosynthesis of the natural product concerned e. Some small sections describe problems associated with structure elucidation, which then led to revision of the supposed structure in the context of the total synthesis e.

The very instructive concept of discussing and comparing several different syntheses of a target structure in a parallel fashion, which was introduced in the second volume of this series, has now been further developed in a clever way. Sometimes it would also have been useful for the synthetic chemist reader to be given an explanation of why a specific unusual reagent was chosen at a certain stage during the planning or carrying out of a synthesis, and why an apparently more convenient and conventional procedure was avoided.

Wiley-VCH – Classics in Total Synthesis III

Such explanations, and possibly also descriptions of unsuccessful attempted routes, could give the reader an even more detailed insight into problems of reactivity or selectivity of a specific reagent or substrate. The layout of this book has only been slightly changed compared with previous volumes. One innovation is the introduction of a colored title page at the beginning of each chapter, presenting an attractive graphical illustration of the target structure, together with its natural source and a picture of the leader of the group that worked on the total synthesis.


However, the opportunity to similarly illustrate other parts of the chapter has not been taken; especially in the introduction, figures or graphics in color might have improved the accessibility of the contents. On the other hand, the great success clasics this series does support a continuation of the style in its present form. As the selection of synthetic target molecules for this syjthesis is exclusively taken from syntheis more recent literature, in contrast syntjesis the first volume of the series, it remains to be seen whether the syntheses described will eventually become true classics.

This book will certainly contribute its share to ensuring that these syntheses will be used as outstanding models for teaching and research synthfsis, even 20 or more years from now.

Nicolaou has made outstanding contributions in his research field. A particularly extensive account is given in Chapter 3, which describes an impressive 60 g total synthesis of discodermolide by Novartis. This clearly demonstrates the increasing scientific, but also industrial, importance of complex syntheses of natural products. The present volume – and hopefully future books of this series – offer an exciting and outstanding overview of the subject of natural products total syntheses in its complexity and variety.

Classics in Total Synthesis III will surely itself become a classic in the literature on the state of clzssics art of contemporary organic synthetic chemistry.

Book Review: Classics in Total Synthesis – K. C. Nicolaou, E. J. Sorensen

His impact on chemistry, biology and medicine flows from his research works in chemical synthesis and chemical biology described in numerous publications and patens.

He is the recipient of many prizes, awards and honors. Chen received his A. After two years as a medicinal chemist at Enanta Pharmaceuticals, he began graduate studies at The Scripps Research Institute under the guidance of Professor K. He currently is a post-doctoral clasxics in Professor Nicolaou’s laboratory.